Contact Info:
- Email: clinicaltrials@cabalettabio.com
- Phone: +1 (267) 759-3100
A phase 1/ 2 clinical trial, investigating a treatment that uses your own T cells to treat myositis
Who Can Participate:
- Children ages 6+ and adults with active myositis (JDM, JPM, or adult forms)
- Must have active disease
- Learn more here
A study physician will determine final eligibility.
How It Works:
- T cells are extracted from the patient, reengineered into CAR T cells, and returned to the patient to target harmful immune cells that may be causing disease
- All participants in the RESET-Myositis Trial will receive CAR-T cell therapy— there is no placebo group in this study
- Learn more about the CAR-T process and how it works here
The trial is enrolling at multiple locations across the U.S., including:
Accepting Juvenile Patients:
Pediatric sites typically accept patients age 6 through age 26-28. Patients over the age of 18 are encouraged to contact both the juvenile and adult site nearest them for additional eligibility information.
- San Francisco, CA. UCSF. Contact: Zilan Zheng, 415-353-1301, zilan.zheng@ucsf.edu
- Aurora, CO. Children’s Hospital Colorado. Contact: Dr. Kentaro Yomogida, kentaro.yomogida@childrenscolorado.org
- St. Petersburg, FL. Johns Hopkins All Children’s Hospital. Contact: Jhanvi Patel, 727-767-2946, jpatel77@jh.edu
- Atlanta, GA. Children’s Healthcare of Atlanta. Contact: Judson Russell, 404-785-7263, judson.russell@choa.org
- Chicago, IL. Ann & Robert H. Lurie Children’s Hospital of Chicago. Contact: Tyler Sorensen, 312-277-6828, tsorensen@luriechildrens.org
- Chicago, IL. University of Chicago Medical Center. Contact: Dr. Cuoghi Edends, cedens@bsd.uchicago.edu
- Boston, MA. Boston Children’s Hospital. Contact: Kyle McBrearty, 617-355-2780, kyle.mcbrearty@childrens.harvard.edu
- Ann Arbor, MI. University of Michigan. Contact: Abigail Whalen, 734-615-4466, abigaiwh@med.umich.edu
- New York, NY. Hospital for Special Surgery. Contact: Janvi Bhatia, 212-774-2123, bhatiaj@hss.edu
- New York, NY. Memorial Sloan Kettering. Contact: Atifah Osrat, 646-608-2091, osrata1@mskcc.org
- Bronx, NY. Children’s Hospital at Montefiore. Contact: Emily Gillies, 718-696-2402, egillies@montefiore.org
- Durham, NC. Duke University Medical Center. Contact: Lynn Rodgers, 919-668-2953, Lynn.rodgers@duke.edu
- Philadelphia, PA. Children’s Hospital of Philadelphia. Contact: CARTintake@chop.edu
- Dallas, TX. UT Southwestern Medical Center. Contact: Dr. Samuel John, dtpteam@childrens.com
- Seattle, WA. Seattle Children’s Research Institute. Contact: Dr. Susan Shenoi, 206-987-2193, susan.shenoi@SeattleChildrens.org
Accepting Adult Patients:
- Irvine, CA. University of California Irvine. Contact: Alpha Clinic, 949-824-3990, alphaclinic@uci.edu
- Jacksonville, FL. Mayo Clinic Florida. Contact: Wesley Dillinger, 904-953-3626, dillinger.wesley@mayo.edu
- Atlanta, GA. Emory University. Contact: Trinh Van, 404-712-3940, trinh.van@emory.edu
- Chicago, IL. Northwestern Memorial Hospital. Contact: Kaitlin King, 312-695-0990, autoimmunesct@nm.org
- Chicago, IL. University of Chicago Medical Center. Contact: Dr. Iazsmin Ventura, 773-702-6619, iventura@uchicago.edu
- Kansas City, KS. University of Kansas Medical Center. Contact: Samantha Colgan, 913-945-9938, scolgan@kumc.edu
- Rochester, MN. Mayo Clinic. Contact: Bridget Neja, 507-266-9150, neja.bridget@mayo.edu
- New York, NY. Hospital for Special Surgery. Contact: Janvi Bhatia, 212-774-2123, bhatiaj@hss.edu
- New York, NY. Memorial Sloan Kettering. Contact: Atifah Osrat, 646-608-2091, osrata1@mskcc.org
- Chapel Hill, NC. University of North Carolina at Chapel Hill. Contact: Jennifer Poole, jennifer_poole@med.unc.edu
- Portland, OR. Oregon Health & Science University. Contact: Katie Lewis, 503-908-9724, lewiskat@ohsu.edu
- Pittsburgh, PA. UPMC Arthritis and Autoimmunity Center. Contact: Laurie Hope, hopelk@upmc.edu
- Nashville, TN. Vanderbilt University Medical Center. Contact: Nur Ali, 615-875-5106, nur.ali@vumc.org
- Houston, TX. Houston Methodist Hospital. Contact: Amelia A. Nounes, 346-356-3639, aanounes@houstonmethodist.org
- Houston, TX. University of Texas MD Anderson Cancer Center. Contact: Christina Amos Briggs, 713-563-5076, aanounes@houstonmethodist.org
*Each children’s hospital may have slightly different maximum age guidelines, please contact clinicaltrials@cabalettabio.com to learn more
Travel:
- Travel to one of the sites may be covered, please contact to learn more
- In some cases, families who live more than approximately two hours from the trial site may choose or be asked to remain near the hospital for up to two weeks following treatment.
Want to learn more?
Talk to your doctor or email the study team at clinicaltrials@cabalettabio.com
Read more about this trial on clinicaltrials.gov
New Publication in Nature Biotechnology
A recent publication reviews the clinical progress of cellular immunotherapies for autoimmune diseases, including data from the RESET program evaluating rese-cel.
The full publication can be found here.
