Clinical trials are medical research studies in which people participate as volunteers. They help researchers learn more about diseases and conditions and develop new treatments and medications. Learn more about clinical trials here.
Below are clinical trials currently recruiting juvenile myositis patients. JDM and JPM patients of various ages may be eligible for these trials. For detailed information about a particular trial, please contact the study team directly.
If you have any questions, please contact Cure JM’s Family and Clinician Education Manager, Ashley Renfrow, RN, NP-C, at ashley.renfrow@curejm.org.
Cabaletta Bio CAR-T trial
RESET-Myositis: Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects with Active Idiopathic Inflammatory Myopathy
Idiopathic inflammatory myopathies (IIMs, or myositis) are a group of rare autoimmune diseases characterized by inflammation and muscle weakness. Though the cause of IIM is not well understood, some subtypes of IIM, including dermatomyositis (DM), anti-synthetase syndrome (ASyS), and immune-mediated necrotizing myopathy (IMNM), are thought to involve B cells that cause the body to attack different tissues in the body. This study is being conducted to evaluate the safety and efficacy of an investigational cell therapy, CABA-201, that can be given to patients with DM, ASyS, and IMNM who have active disease. A single dose of CABA-201 in combination with cyclophosphamide (CY) and fludarabine (FLU) will be evaluated.
Are you wondering if this clinical trial is right for you? To find out more, contact the study team using the information below.
Phone: +1-267-759-3100
Century Therapeutics CAR-NK trial
JDM and JPM patients age 17+ are eligible to participate; please contact one of the sites listed here. This study is called the CALiPSO-1 Study. It is a study of CNTY-101, which is a CD19-targeted CAR-NK Cell Product. This is being tested in participants with refractory B Cell-mediated autoimmune diseases like JDM and JPM.
Note: You may see the term “IIM” listed on the trial site. In medicine, IIM stands for Idiopathic Inflammatory Myopathies. IIM refers to the group of rare diseases is characterized by chronic muscle inflammation and includes conditions like JDM, JPM, and others.
If you have any questions, please contact Cure JM’s Family and Clinician Education Manager, Ashley Renfrow, RN, NP-C, at ashley.renfrow@curejm.org.
