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Cure JM Currently Funded Research

Complement C4 in Disease Risk and Pathogenesis of Juvenile Dermatomyositis

This study will analyze whether variations of C4A genes and changes of C4 proteins can be used to reveal the severity of JDM and how the illness may develop. The research team will analyze hundreds of DNA samples from JDM patients and healthy subjects. They will use cutting-edge techniques to perform experiments -some of the techniques were originally designed by this research team, who are pioneers in the research field of immune genetics. They hope, through their research, to be able to develop better and more specific ways to diagnose and treat the disease, and hopefully to find a cure in the future.

Novel Biomarkers Associated with Disease Activity in JDM

This study will compare and contrast serum markers and gene expression patterns in JDM with those of other closely related disorders (CANDLE and SAVI) with the hopes of better understanding the cause(s) of JDM and possible treatments. The study also intends to identify dysregulated pathways in JDM using RNA-Sequencing to improve biomarkers related to disease activity. By developing a better biomarker, the research team hopes to better predict who will respond to a particular therapy, indicate when to stop and start therapy and develop more JDM-specific therapies in the future.

Predictive Model of Disease Outcomes using Computational Biology Modeling in Children with Inflammatory Muscle Disease

Research study at the Mayo Clinic to determine associations between disease outcomes and various features of JDM, which may lead to the prediction of which patients would benefit from particular treatment choices.

Lymphocyte Repertoire in Juvenile Dermatomyositis

Research study at Boston Children's Hospital using "next generation sequencing" to study detailed T & B cell differences in JDM. This should lead to a better understanding of changes in the immune system, which may help to advance the understanding of JDM and improve future outcomes.

Premature Atherosclerosis in Juvenile Dermatomyositis

Research study at Children's Hospital at Montefiore that aims to identify which risk factors may be the most significant indicators of early heart disease in children with JDM.

Simultaneous Genomics and Microbiotica Phenotyping in Juvenile Dermatomyositis (JDM)

Long Term Aim: To identify specific oral and fecal microbial communities in JDM that may be targeted in future therapeutic trials. The influences of susceptibility genotypes for known immune function genes and dietary elements known to alter the microbiome will be characterized to provide the rationale for future diagnostic and therapeutic trials.

Cure JM Program of Excellence in Juvenile Myositis  Research at Stanley Manne Children’s Research Institute of Ann & Robert H. Lurie Children’s Hospital of Chicago

Dr. Lauren Pachman, the Principle Investigator and Director, has cared for over 550 children with JDM and other forms of inflammatory myopathy. Dr. Pachman has patients who travel from around the country to see her for a diagnosis and/or treatment.  She is also called upon for consults and referrals from other doctors.  Her team is working to discover the biomarkers of JM activity to guide the utilization and/or creation of more effective therapies. They have already identified a variety of genetic and environmental factors that not only play a role in the onset of symptoms, but also govern the child's outcome.

George Washington University Myositis Center

Multidisciplinary effort made possible by a grant from Cure JM Foundation. As a national referral site for inflammatory muscle diseases, the Center is often called upon to either establish a diagnosis or to provide a second opinion related to the management of children and adults with JM. Working in collaboration with the NIH, the Center also specializes in JM research and education.

International Consensus Conference 

Myositis researchers from around the world came together to develop standard measures of “improvement” for myositis patients. These new measures are critical for research, as they will be the end goals for future myositis clinical trials. Plus, this should help facilitate future drug development for JM.

Genetic Risk Factors for Calcinosis   

Research study at Stanford University utilizing previously collected blood samples to look at certain genes and potentially determine their role in the development of calcinosis

Gastrointestinal Bacterial Tract in JM Patients 

Pilot study at Seattle Children’s Hospital to determine if the proliferation of oral and intestinal pathogens could lead to the activation of JM

Predictive Model of Disease Outcomes using Computational Biology Modeling in Children With Inflammatory Muscle Disease

Research study at the Mayo Clinic to determine associations between disease outcomes and various features of JDM, which may lead to the prediction of which patients would benefit from particular treatment choices

Lymphocyte Repertoire in Juvenile Dermatomyositis

Research study at Boston Children’s Hospital using “next generation sequencing” to study detailed T & B cell differences in JDM. This should lead to a better understanding of changes in the immune system, which may help to advance the understanding of JDM and improve future outcomes.

Premature Atherosclerosis in Juvenile Dermatomyositis

Research study at Children’s Hospital at Montefiore that aims to identify which risk factors may cause the greatest risk of early heart disease in children with JDM


Summary of Cure JM Supported Research, 2006-2013

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