Cure JM Currently Funded Studies

Cure JM Foundation was founded with the primary goal of finding a cure for Juvenile Myositis. To that end, most of the donations we raise go into the funding of research exploring the genesis of JM, more effective treatments for JM and potential cures for JM.

Among some of our more notable accomplishments has been the funding of the Cure JM Program of Excellence in JM Research at Children’s Memorial Research Center in Chicago, as well as grants extended to the JM research and treatment center at The George Washington University in Washington, D.C. We would like to thank all those who helped make this possible and who are continuing to raise awareness and funds for further JM research.

Complement C4 in Disease Risk and Pathogenesis of Juvenile Dermatomyositis

Chack-Yung Yu, D.Phil., Professor of Pediatrics; Professor of Molecular Virology, Immunology and Medical Genetics, Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH
This study will analyze whether variations of C4A genes and changes of C4 proteins can be used to reveal the severity of JDM and how the illness may develop. The research team will analyze hundreds of DNA samples from JDM patients and healthy subjects. They will use cutting-edge techniques to perform experiments -some of the techniques were originally designed by this research team, who are pioneers in the research field of immune genetics. They hope, through their research, to be able to develop better and more specific ways to diagnose and treat the disease, and hopefully to find a cure in the future.

Novel Biomarkers Associated with Disease Activity in JDM

Hanna Kim, MD, Fellow, Division of Pediatric Rheumatology Children's National Medical Center and National Institutes of Health
This study will compare and contrast serum markers and gene expression patterns in JDM with those of other closely related disorders (CANDLE and SAVI) with the hopes of better understanding the cause(s) of JDM and possible treatments. The study also intends to identify dysregulated pathways in JDM using RNA-Sequencing to improve biomarkers related to disease activity. By developing a better biomarker, the research team hopes to better predict who will respond to a particular therapy, indicate when to stop and start therapy and develop more JDM-specific therapies in the future.

Predictive Model of Disease Outcomes using Computational Biology Modeling in Children with Inflammatory Muscle Disease

Ann Reed, MD

Research study at the Mayo Clinic to determine associations between disease outcomes and various features of JDM, which may lead to the prediction of which patients would benefit from particular treatment choices.

Lymphocyte Repertoire in Juvenile DermatomyositisSusan Kim, MD

Susan Kim, MD
Research study at Boston Children's Hospital using "next generation sequencing" to study detailed T & B cell differences in JDM. This should lead to a better understanding of changes in the immune system, which may help to advance the understanding of JDM and improve future outcomes.

Premature Atherosclerosis in Juvenile Dermatomyositis

Dawn Wahezi, MD
Research study at Children's Hospital at Montefiore that aims to identify which risk factors may be the most significant indicators of early heart disease in children with JDM.

Simultaneous Genomics and Microbiotica Phenotyping in Juvenile Dermatomyositis (JDM)

Dr. Anne Stevens, MD, PhD. Seattle Children's Research Institute
Long Term Aim: To identify specific oral and fecal microbial communities in JDM that may be targeted in future therapeutic trials. The influences of susceptibility genotypes for known immune function genes and dietary elements known to alter the microbiome will be characterized to provide the rationale for future diagnostic and therapeutic trials.

Summary of Cure JM Supported Research, 2006-2013

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